HYOSCYAMINE

Anaspaz, Levbid, Levsin/SL, Levsinex, Levsin, NuLev

DOSING IN  ADULTS Oral or S.L.: 0.125-0.25 mg every 4 hours or as needed (before meals or food); maximum: 1.5 mg/24 hours Oral, timed release: 0.375-0.75 mg every 12 hours; maximum: 1.5 mg/24 hours

DOSAGE FORMS

Capsule, timed release, as sulfate (Levsinex): 0.375 mg Elixir, as sulfate: 0.125 mg/5 mL (480 mL) Levsin: 0.125 mg/5 mL (480 mL) Tablet, as sulfate (Anaspaz, Levsin): 0.125 mg Tablet, extended release, as sulfate (Levbid) 0.375 mg Tablet, orally disintegrating, as sulfate (NuLev): 0.125 mg Tablet, sublingual, as sulfate: 0.125 mg

SIGNIFICANT ADVERSE REACTIONS

Dry mouth Palpitation Dizziness Lactation suppression Bloating Constipation Urinary retention Blurred vision Decreased Sweating

CONTRAINDICATIONS — Hypersensitivity to belladonna alkaloids or any component of the formulation; glaucoma; obstructive uropathy; myasthenia gravis; obstructive GI tract disease, paralytic ileus, unstable cardiovascular status in acute hemorrhage, myocardial ischemia

DRUG INTERACTIONS

Antacids: Antacids may decrease absorption of hyoscyamine; administer hyoscyamine before meals and give antacids after meals. Antihistamines: Additive adverse effects may occur with some antihistamines due to cholinergic blockade. Antimuscarinics: Additive adverse effects may occur due to cholinergic blockade. Haloperidol: Additive adverse effects may occur due to cholinergic blockade. Phenothiazines: Additive adverse effects may occur due to cholinergic blockade. Tricyclic antidepressants: Additive adverse effects may occur due to cholinergic blockade.

PREGNANCY RISK FACTOR — C

LACTATION — Enters breast milk/not recommended